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The solution structure of the regulatory domain of tyrosine hydroxylase

Analyse The solution structure of the regulatory domain of tyrosine hydroxylase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2MDA
Type: protein
Length: 190 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosine 3-monooxygenase
UniProt: P04177
Pockets: 4 · best druggability 0.58

Structure

solution nmr · 1 distinct chain · 20% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Tyrosine 3-monooxygenase	protein	95	20% helix, 24% strand	P04177

Pockets

4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	123	0.58	0.84	22	empty
2	103	0.53	0.83	21	empty
3	114	0.53	0.82	20	empty
4	110	0.52	0.82	21	empty

Interfaces

1 interface between chains.

A–B · 933 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

2MDA · The Solution Structure of the Regulatory Domain of Tyrosine Hydroxylase · the same entry in another collection · chain A against A, TM-score 1.00
P04177 · AlphaFold monomer V2.0 prediction for tyrosine 3-monooxygenase (P04177) · a predicted model of the same protein · chain A against A, TM-score 0.69

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P04177
Elsewhere: RCSB PDB 2MDA · PDBe 2MDA · UniProt P04177

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