Research workbench
40-residue beta-amyloid fibril derived from ALZHEIMER'S disease brain
Analyse 40-residue beta-amyloid fibril derived from ALZHEIMER'S disease brain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2M4J
- Type
- protein
- Length
- 360 residues
- Chains
- 9
- Method
- solid-state nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Amyloid beta A4 protein
- UniProt
- P05067
Structure
solid-state nmr · 1 distinct chain · 0% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I | Amyloid beta A4 protein | protein | 40 | 0% helix, 20% strand | P05067 |
Interfaces
27 interfaces between chains.
- E–H · 1670 Ų buried · 31 hydrogen bonds · protein-protein
- B–E · 1663 Ų buried · 31 hydrogen bonds · protein-protein
- A–D · 1662 Ų buried · 32 hydrogen bonds · protein-protein
- F–I · 1661 Ų buried · 31 hydrogen bonds · protein-protein
- D–G · 1658 Ų buried · 31 hydrogen bonds · protein-protein
Compared structures
- 2M4J · 40-residue beta-amyloid fibril derived from Alzheimer's disease brain · the same entry in another collection · chain I against I, TM-score 1.00
- P05067 · AlphaFold monomer V2.0 prediction for amyloid-beta precursor protein (P05067) · a predicted model of the same protein · chain I against A, TM-score 0.34
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05067
- Elsewhere: RCSB PDB 2M4J · PDBe 2M4J · UniProt P05067
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