Research workbench
Structural insights into human S100B and basic fibroblast growth factor (FGF2) interaction
Analyse Structural insights into human S100B and basic fibroblast growth factor (FGF2)… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2M49
- Type
- protein
- Length
- 434 residues
- Chains
- 4
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fibroblast growth factor 2; Protein S100-B
- UniProt
- P09038, P04271
- Pockets
- 5 · best druggability 0.50
Structure
solution nmr · 2 distinct chains · 24% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Fibroblast growth factor 2 | protein | 126 | 5% helix, 46% strand | P09038 |
| B, D | Protein S100-B | protein | 91 | 51% helix, 0% strand | P04271 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 148 | 0.50 | 0.79 | 20 | empty |
| 2 | 128 | 0.47 | 0.78 | 16 | empty |
| 3 | 172 | 0.45 | 0.75 | 27 | empty |
| 4 | 134 | 0.40 | 0.74 | 31 | empty |
| 5 | 52 | 0.26 | 0.73 | 19 | empty |
Interfaces
3 interfaces between chains.
- B–D · 1302 Ų buried · 6 hydrogen bonds · protein-protein
- D–C · 827 Ų buried · 17 hydrogen bonds · protein-protein
- A–B · 807 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 2M49 · Structural Insights into Human S100B and Basic Fibroblast Growth Factor (FGF2) Interaction · the same entry in another collection · chain A against A, TM-score 1.00
- P09038 · AlphaFold monomer V2.0 prediction for fibroblast growth factor 2 (P09038) · a predicted model of the same protein · chain C against A, TM-score 0.99
- P04271 · AlphaFold monomer V2.0 prediction for protein S100-B (P04271) · a predicted model of the same protein · chain B against A, TM-score 0.71
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09038
- Every structure of UniProt P04271
- Elsewhere: RCSB PDB 2M49 · PDBe 2M49 · UniProt P09038 · UniProt P04271
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.