Research workbench
Structural mechanism for bax inhibition by cytomegalovirus protein vmia
Analyse Structural mechanism for bax inhibition by cytomegalovirus protein vmia in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2LR1
- Type
- protein
- Length
- 213 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Apoptosis regulator bax; Immediate early glycoprotein
- UniProt
- Q07812, P16778
- Pockets
- 4 · best druggability 0.67
Structure
solution nmr · 2 distinct chains · 60% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Apoptosis regulator bax | protein | 192 | 63% helix, 0% strand | Q07812 |
| B | Immediate early glycoprotein | protein | 21 | 38% helix, 0% strand | P16778 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 186 | 0.67 | 0.85 | 39 | empty |
| 2 | 333 | 0.56 | 0.75 | 36 | empty |
| 3 | 99 | 0.43 | 0.78 | 17 | empty |
| 4 | 53 | 0.40 | 0.81 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 187 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2LR1 · Structural Mechanism for Bax Inhibition by Cytomegalovirus Protein vMIA · the same entry in another collection · chain A against A, TM-score 1.00
- Q07812 · AlphaFold monomer V2.0 prediction for apoptosis regulator bax (Q07812) · a predicted model of the same protein · chain A against A, TM-score 0.84
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q07812
- Every structure of UniProt P16778
- Elsewhere: RCSB PDB 2LR1 · PDBe 2LR1 · UniProt Q07812 · UniProt P16778
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