Research workbench
Solution NMR structure of cam bound to inos cam binding domain peptide
Analyse Solution NMR structure of cam bound to inos cam binding domain peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2LL6
- Type
- protein
- Length
- 165 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calmodulin; Nitric oxide synthase, inducible
- EC
- 1.14.13.39
- UniProt
- P62158, P35228
- Pockets
- 3 · best druggability 0.64
Structure
solution nmr · 2 distinct chains · 57% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calmodulin | protein | 148 | 55% helix, 5% strand | P62158 |
| B | Nitric oxide synthase, inducible (EC 1.14.13.39) | protein | 17 | 71% helix, 0% strand | P35228 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 236 | 0.64 | 0.82 | 32 | empty |
| 2 | 111 | 0.52 | 0.81 | 18 | empty |
| 3 | 107 | 0.43 | 0.77 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 1370 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2LL6 · Solution NMR structure of CaM bound to iNOS CaM binding domain peptide · the same entry in another collection · chain B against B, TM-score 1.00
- P35228 · AlphaFold monomer V2.0 prediction for nitric oxide synthase, inducible (P35228) · a predicted model of the same protein · chain B against A, TM-score 0.48
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62158
- Every structure of UniProt P35228
- Elsewhere: RCSB PDB 2LL6 · PDBe 2LL6 · UniProt P62158 · UniProt P35228
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