UniProt P35228
Nitric oxide synthase, inducible (P35228)
Nitric oxide synthase, inducible (UniProt P35228), EC 1.14.13.39: 22 experimental structures and 1 predicted model on GenesisL1, 13 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P35228
- Protein
- Nitric oxide synthase, inducible
- EC
- 1.14.13.39
- Experimental structures
- 22
- Predicted models
- 1
- Pockets
- 13 · 1 record with a druggable one
Structures
23 records of P35228 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1NSI | Human inducible nitric oxide synthase, zn-bound, L-arg complex | x-ray diffraction | A, B, C, D | — | — |
| 1NSI | Human inducible nitric oxide synthase, zn-bound, L-arg complex | x-ray diffraction | A, B, C, D | — | — |
| 2LL6 | Solution NMR structure of CaM bound to iNOS CaM binding domain peptide | solution nmr | B | — | — |
| 2LL6 | Solution NMR structure of cam bound to inos cam binding domain peptide | solution nmr | B | — | — |
| 2NSI | Human inducible nitric oxide synthase, zn-free, seitu complex | x-ray diffraction | A, B, C, D | — | — |
| 2NSI | Human inducible nitric oxide synthase, zn-free, seitu complex | x-ray diffraction | A, B, C, D | — | — |
| 3E7G | Structure of human INOSOX with inhibitor AR-C95791 | x-ray diffraction | A, B, C, D | — | — |
| 3E7G | Structure of human inosox with inhibitor ar-C95791 | x-ray diffraction | A, B, C, D | — | — |
| 3EJ8 | Structure of double mutant of human iNOS oxygenase domain with bound immidazole | x-ray diffraction | A, B, C, D | — | — |
| 3EJ8 | Structure of double mutant of human inos oxygenase domain with bound immidazole | x-ray diffraction | A, B, C, D | — | — |
| 3HR4 | Human iNOS Reductase and Calmodulin Complex | x-ray diffraction | A, C, E, G | — | — |
| 3HR4 | Human inos reductase and calmodulin complex | x-ray diffraction | A, C, E, G | — | — |
| 4CX7 | Structure of human iNOS heme domain in complex with (R)-6-(3-AMINO-2-(5-(2-(6-AMINO-4… | x-ray diffraction | A, B, C, D | — | — |
| 4CX7 | Structure of human inos heme domain in complex with (R)-6-( 3-amino-2-(5-(2-(6-amino-4… | x-ray diffraction | A, B, C, D | — | — |
| 4NOS | Human inducible nitric oxide synthase with inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 4NOS | Human inducible nitric oxide synthase with inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 5TP6 | Solution structure of the CAM34 with the inos cam binding domain peptide | solution nmr | B | — | — |
| 6JWM | Crystal structure of the SPRY domain of SPSB2 in complex with cR7, a potent cyclic peptide… | x-ray diffraction | B | — | — |
| 6JWM | Crystal structure of the spry domain of SPSB2 in complex with CR7, a potent cyclic peptide… | x-ray diffraction | B | — | — |
| 6JWN | Crystal structure of the spry domain of SPSB2 in complex with CR9, a cyclic peptide inhibitor of… | x-ray diffraction | B, D | — | — |
| 6KEY | Structural basis for the regulation of inducible nitric oxide synthase (iNOS) by the SPRY… | x-ray diffraction | B | — | — |
| 6KEY | Structural basis for the regulation of inducible nitric oxide synthase (inos) by the spry… | x-ray diffraction | B | — | — |
| P35228 | AlphaFold monomer V2.0 prediction for nitric oxide synthase, inducible (P35228) | predicted | A | — | 13 (best 0.80) |
Experiment against prediction
- 4CX7 chain A against the predicted model P35228: TM-score 0.99, RMSD 0.74 Å
- 4CX7 chain A against the predicted model P35228: TM-score 0.99, RMSD 0.74 Å
- 2NSI chain A against the predicted model P35228: TM-score 0.99, RMSD 0.78 Å
- 2NSI chain A against the predicted model P35228: TM-score 0.99, RMSD 0.78 Å
- 3E7G chain A against the predicted model P35228: TM-score 0.99, RMSD 0.79 Å
- 3E7G chain A against the predicted model P35228: TM-score 0.99, RMSD 0.79 Å
- 3E7G chain C against the predicted model P35228: TM-score 0.99, RMSD 0.81 Å
- 3E7G chain C against the predicted model P35228: TM-score 0.99, RMSD 0.81 Å
- 4NOS chain A against the predicted model P35228: TM-score 0.99, RMSD 0.80 Å
- 4NOS chain A against the predicted model P35228: TM-score 0.99, RMSD 0.80 Å
Elsewhere
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