Research workbench
Solution structure of the core smn-GEMIN2 complex
Analyse Solution structure of the core smn-GEMIN2 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2LEH
- Type
- protein
- Length
- 215 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Survival of motor neuron protein-interacting protein 1; Survival motor neuron protein
- UniProt
- O14893, Q16637
- Pockets
- 3 · best druggability 0.82
Structure
solution nmr · 2 distinct chains · 54% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Survival of motor neuron protein-interacting protein 1 | protein | 189 | 56% helix, 0% strand | O14893 |
| B | Survival motor neuron protein | protein | 26 | 42% helix, 0% strand | Q16637 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1120 | 0.82 | 0.83 | 94 | empty |
| 2 | 54 | 0.61 | 0.92 | 16 | empty |
| 3 | 73 | 0.32 | 0.75 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 851 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 2LEH · Solution structure of the core SMN-Gemin2 complex · the same entry in another collection · chain A against A, TM-score 1.00
- O14893 · AlphaFold monomer V2.0 prediction for gem-associated protein 2 (O14893) · a predicted model of the same protein · chain A against A, TM-score 0.68
- Q16637 · AlphaFold monomer V2.0 prediction for survival motor neuron protein (Q16637) · a predicted model of the same protein · chain B against A, TM-score 0.44
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14893
- Every structure of UniProt Q16637
- Elsewhere: RCSB PDB 2LEH · PDBe 2LEH · UniProt O14893 · UniProt Q16637
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