Research workbench

Solution structure of human SRSF2 (SC35) rrm in complex with 5'- uggagu-3'

Analyse Solution structure of human SRSF2 (SC35) rrm in complex with 5'- uggagu-3' in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2LEC
Type: protein + RNA
Length: 107 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/ARGININE-rich splicing factor 2; RNA (5'-R(*UP*GP*GP*AP*GP*U)-3')
UniProt: Q01130
Pockets: 1 · best druggability 0.29

Structure

solution nmr · 2 distinct chains · 22% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/ARGININE-rich splicing factor 2	protein	101	22% helix, 15% strand	Q01130
B	RNA (5'-R(UPGPGPAPGPU)-3')	rna	6	—	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	61	0.29	0.74	14	empty

Interfaces

1 interface between chains.

A–B · 959 Å² buried · 25 hydrogen bonds · protein-nucleic

Compared structures

2LEC · Solution structure of human SRSF2 (SC35) RRM in complex with 5'-UGGAGU-3' · the same entry in another collection · chain A against A, TM-score 1.00
Q01130 · AlphaFold monomer V2.0 prediction for SERINE/ARGININE-rich splicing factor 2 (Q01130) · a predicted model of the same protein · chain A against A, TM-score 0.74

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q01130
Elsewhere: RCSB PDB 2LEC · PDBe 2LEC · UniProt Q01130

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.