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Solution structure of the hmg box DNA-binding domain of human stem cell transcription factor SOX2

Analyse Solution structure of the hmg box DNA-binding domain of human stem cell… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2LE4
Type: protein
Length: 81 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcription factor sox-2
UniProt: P48431
Pockets: 1 · best druggability 0.30

Structure

solution nmr · 1 distinct chain · 58% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcription factor sox-2	protein	81	58% helix, 0% strand	P48431

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	72	0.30	0.73	15	empty

Compared structures

2LE4 · Solution structure of the HMG box DNA-binding domain of human stem cell transcription… · the same entry in another collection · chain A against A, TM-score 1.00
P48431 · AlphaFold monomer V2.0 prediction for transcription factor sox-2 (P48431) · a predicted model of the same protein · chain A against A, TM-score 0.51

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P48431
Elsewhere: RCSB PDB 2LE4 · PDBe 2LE4 · UniProt P48431

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