Research workbench
Structure of first ww domain of human yap in complex with a human SMAD1 doubly-phosphorilated derived peptide.
Analyse Structure of first ww domain of human yap in complex with a human SMAD1… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2LAX
- Type
- protein
- Length
- 45 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Yorkie homolog; Mothers against decapentaplegic homolog 1
- UniProt
- P46937, Q15797
Structure
solution nmr · 2 distinct chains · 0% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Yorkie homolog | protein | 36 | 0% helix, 42% strand | P46937 |
| B | Mothers against decapentaplegic homolog 1 | protein | 9 | 0% helix, 0% strand | Q15797 |
Interfaces
1 interface between chains.
- A–B · 332 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (phosphorylation).
Compared structures
- 2LAX · Structure of first WW domain of human YAP in complex with a human Smad1… · the same entry in another collection · chain A against A, TM-score 1.00
- P46937 · AlphaFold monomer V2.0 prediction for transcriptional coactivator YAP1 (P46937) · a predicted model of the same protein · chain A against A, TM-score 0.61
- Q15797 · AlphaFold monomer V2.0 prediction for mothers against decapentaplegic homolog 1 (Q15797) · a predicted model of the same protein · chain B against A, TM-score 0.47
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P46937
- Every structure of UniProt Q15797
- Elsewhere: RCSB PDB 2LAX · PDBe 2LAX · UniProt P46937 · UniProt Q15797
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