Research workbench
CKSHS1: human cyclin dependent kinase subunit, type 1 complex with metavanadate
Analyse CKSHS1: human cyclin dependent kinase subunit, type 1 complex with metavanadate in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1DKT
- Type
- protein
- Length
- 143 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cyclin dependent kinase subunit, type 1
- UniProt
- P61024
- Ligands
- V7O
- Pockets
- 1 · best druggability 0.40
Structure
x-ray diffraction · 2 distinct chains · 17% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cyclin dependent kinase subunit, type 1 | protein | 72 | 18% helix, 32% strand | P61024 |
| B | Cyclin dependent kinase subunit, type 1 | protein | 71 | 15% helix, 32% strand | P61024 |
Ligands and binding sites
- V7O · Meta vanadate · ligand · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 87 | 0.40 | 0.78 | 20 | V7O |
Interfaces
1 interface between chains.
- A–B · 474 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 1DKT · CKSHS1: human cyclin dependent kinase subunit, type 1 complex with metavanadate · the same entry in another collection · chain A against A, TM-score 1.00
- P61024 · AlphaFold monomer V2.0 prediction for cyclin-dependent kinases regulatory subunit 1… · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61024
- Elsewhere: RCSB PDB 1DKT · PDBe 1DKT · UniProt P61024
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