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Spatial structure of dimeric ERBB3 transmembrane domain

Analyse Spatial structure of dimeric ERBB3 transmembrane domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2L9U
Type: protein
Length: 80 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Receptor tyrosine-protein kinase erbb-3
EC: 2.7.10.1
UniProt: P21860
Pockets: 1 · best druggability 0.33

Structure

solution nmr · 1 distinct chain · 78% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Receptor tyrosine-protein kinase erbb-3 (EC 2.7.10.1)	protein	40	78% helix, 0% strand	P21860

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	51	0.33	0.77	12	empty

Interfaces

1 interface between chains.

A–B · 472 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

2L9U · Spatial structure of dimeric ErbB3 transmembrane domain · the same entry in another collection · chain A against A, TM-score 1.00
P21860 · AlphaFold monomer V2.0 prediction for receptor tyrosine-protein kinase erbb-3 (P21860) · a predicted model of the same protein · chain B against A, TM-score 0.61

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P21860
Elsewhere: RCSB PDB 2L9U · PDBe 2L9U · UniProt P21860

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