Research workbench

NMR structure of full length APOE3

Analyse NMR structure of full length APOE3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2L7B
Type: protein
Length: 299 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Apolipoprotein E
UniProt: P02649
Pockets: 7 · best druggability 0.70

Structure

solution nmr · 1 distinct chain · 64% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Apolipoprotein E	protein	299	64% helix, 0% strand	P02649

Pockets

7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	60	0.70	0.97	17	empty
2	79	0.65	0.92	22	empty
3	227	0.55	0.78	28	empty
4	131	0.54	0.82	23	empty
5	97	0.48	0.81	23	empty

Compared structures

2L7B · NMR Structure of full length apoE3 · the same entry in another collection · chain A against A, TM-score 1.00
P02649 · AlphaFold monomer V2.0 prediction for apolipoprotein E (P02649) · a predicted model of the same protein · chain A against A, TM-score 0.42

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02649
Elsewhere: RCSB PDB 2L7B · PDBe 2L7B · UniProt P02649

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