UniProt P02649
Apolipoprotein E (P02649)
Apolipoprotein E (UniProt P02649): 47 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 6 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P02649
- Protein
- Apolipoprotein E
- Experimental structures
- 47
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 6 · 0 records with a druggable one
Structures
48 records of P02649 in the MolNFT archive: 47 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1B68 | Apolipoprotein E4 (APOE4), 22K fragment | x-ray diffraction | A | — | — |
| 1B68 | Apolipoprotein E4 (APOE4), 22K fragment | x-ray diffraction | A | — | — |
| 1BZ4 | Apolipoprotein E3 (apo-E3), truncation mutant 165 | x-ray diffraction | A | — | — |
| 1BZ4 | Apolipoprotein E3 (apo-E3), truncation mutant 165 | x-ray diffraction | A | — | — |
| 1EA8 | Apolipoprotein E3 22kD fragment LYS146GLU mutant | x-ray diffraction | A | — | — |
| 1EA8 | Apolipoprotein E3 22KD fragment LYS146GLU mutant | x-ray diffraction | A | — | — |
| 1GS9 | Apolipoprotein E4, 22k domain | x-ray diffraction | A | — | — |
| 1GS9 | Apolipoprotein E4, 22K domain | x-ray diffraction | A | — | — |
| 1H7I | Apolipoprotein E3 22kD fragment LYS146GLN mutant | x-ray diffraction | A | — | — |
| 1H7I | Apolipoprotein E3 22KD fragment LYS146GLN mutant | x-ray diffraction | A | — | — |
| 1LE2 | Structural basis for altered function in the common mutants of human apolipoprotein-E | x-ray diffraction | A | — | — |
| 1LE2 | Structural basis for altered function in the common mutants of human apolipoprotein-E | x-ray diffraction | A | — | — |
| 1LE4 | Structural basis for altered function in the common mutants of human apolipoprotein-E | x-ray diffraction | A | — | — |
| 1LE4 | Structural basis for altered function in the common mutants of human apolipoprotein-E | x-ray diffraction | A | — | — |
| 1LPE | Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E | x-ray diffraction | A | — | — |
| 1LPE | Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E | x-ray diffraction | A | — | — |
| 1NFN | Apolipoprotein E3 (APOE3) | x-ray diffraction | A | — | — |
| 1NFN | Apolipoprotein E3 (APOE3) | x-ray diffraction | A | — | — |
| 1NFO | Apolipoprotein E2 (APOE2, D154A mutation) | x-ray diffraction | A | — | — |
| 1NFO | Apolipoprotein E2 (APOE2, D154A mutation) | x-ray diffraction | A | — | — |
| 1OEF | Peptide of human apoe residues 263-286, NMR, 5 structures at pH 4.8, 37 degrees celsius and… | solution nmr | A | — | — |
| 1OEF | Peptide of human apoe residues 263-286, NMR, 5 structures at pH 4.8, 37 degrees celsius and… | solution nmr | A | — | — |
| 1OEG | Peptide of human apoe residues 267-289, NMR, 5 structures at pH 6.0, 37 degrees celsius and… | solution nmr | A | — | — |
| 1OEG | Peptide of human apoe residues 267-289, NMR, 5 structures at pH 6.0, 37 degrees celsius and… | solution nmr | A | — | — |
| 1OR2 | Apolipoprotein E3 (APOE3) truncation mutant 165 | x-ray diffraction | A | — | — |
| 1OR2 | Apolipoprotein E3 (APOE3) truncation mutant 165 | x-ray diffraction | A | — | — |
| 1OR3 | Apolipoprotein E3 (APOE3), trigonal truncation mutant 165 | x-ray diffraction | A | — | — |
| 1OR3 | Apolipoprotein E3 (APOE3), trigonal truncation mutant 165 | x-ray diffraction | A | — | — |
| 2KC3 | NMR solution structure of complete receptor binding domain of human apolipoprotein E | solution nmr | A | — | — |
| 2KC3 | NMR solution structure of complete receptor binding domain of human apolipoprotein E | solution nmr | A | — | — |
| 2KNY | Fusion construct of CR17 from LRP-1 and ApoE residues 130-149 | solution nmr | A | — | — |
| 2KNY | Fusion construct of CR17 from lrp-1 and apoe residues 130-149 | solution nmr | A | — | — |
| 2L7B | NMR Structure of full length apoE3 | solution nmr | A | — | — |
| 2L7B | NMR structure of full length APOE3 | solution nmr | A | — | — |
| 6IWB | Crystal structure of a computationally designed protein (LD3) in complex with BCL-2 | x-ray diffraction | A, C | SO4 | — |
| 6NCN | Fragment-based Discovery of an apoE4 Stabilizer | x-ray diffraction | A | KJM | — |
| 6NCN | Fragment-based discovery of an APOE4 stabilizer | x-ray diffraction | A | KJM | — |
| 6NCO | Fragment-based discovery of an APOE4 stabilizer | x-ray diffraction | A | KQP | — |
| 6V7M | Crystal structure of a proteolytically cleaved, amino terminal domain of apolipoprotein E3 | x-ray diffraction | A, B | PO4 | — |
| 6V7M | Crystal structure of a proteolytically cleaved, amino terminal domain of apolipoprotein E3 | x-ray diffraction | A, B | PO4 | — |
| 7FCR | Crystal structure of the N-terminal domain of mutants of Human Apolipoprotein-E (ApoE) | x-ray diffraction | A | NA | — |
| 7FCR | Crystal structure of the N-terminal domain of mutants of human apolipoprotein-E (apoe) | x-ray diffraction | A | NA | — |
| 7FCS | Crystal structure of the N-terminal domain of mutants of Human Apolipoprotein-E (ApoE) | x-ray diffraction | A | NA | — |
| 7FCS | Crystal structure of the N-terminal domain of mutants of human apolipoprotein-E (apoe) | x-ray diffraction | A | NA | — |
| 8CDY | N-terminal domain of human apolipoprotein E | x-ray diffraction | A | — | — |
| 8CE0 | N-terminal domain of human apolipoprotein E | x-ray diffraction | A | — | — |
| 8GRX | APOE4 receptor in complex with APOE4 NTD | electron microscopy | A, C | — | 6 (best 0.50) |
| P02649 | AlphaFold monomer V2.0 prediction for apolipoprotein E (P02649) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7FCS chain A against the predicted model P02649: TM-score 0.97, RMSD 0.85 Å
- 7FCS chain A against the predicted model P02649: TM-score 0.97, RMSD 0.85 Å
- 7FCR chain A against the predicted model P02649: TM-score 0.97, RMSD 0.94 Å
- 7FCR chain A against the predicted model P02649: TM-score 0.97, RMSD 0.94 Å
- 1NFO chain A against the predicted model P02649: TM-score 0.97, RMSD 0.95 Å
- 1NFO chain A against the predicted model P02649: TM-score 0.97, RMSD 0.95 Å
- 1NFN chain A against the predicted model P02649: TM-score 0.97, RMSD 0.93 Å
- 1NFN chain A against the predicted model P02649: TM-score 0.97, RMSD 0.93 Å
- 6NCN chain A against the predicted model P02649: TM-score 0.96, RMSD 1.03 Å
- 6NCN chain A against the predicted model P02649: TM-score 0.96, RMSD 1.03 Å
Elsewhere
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