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Solution NMR structure of MED25(391-543) comprising the activator- interacting domain (acid) of human mediator subuniti 25. northeast structural genomics consortium target HR6188A

Analyse Solution NMR structure of MED25(391-543) comprising the activator- interacting… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2L6U
Type: protein
Length: 163 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mediator complex subunit MED25
UniProt: Q71SY5
Pockets: 2 · best druggability 0.38

Structure

solution nmr · 1 distinct chain · 18% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mediator complex subunit MED25	protein	163	18% helix, 33% strand	Q71SY5

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	105	0.38	0.75	20	empty
2	58	0.27	0.74	13	empty

Compared structures

2L6U · Solution NMR Structure of Med25(391-543) Comprising the Activator-Interacting Domain… · the same entry in another collection · chain A against A, TM-score 1.00
Q71SY5 · AlphaFold monomer V2.0 prediction for mediator of RNA polymerase II transcription subunit… · a predicted model of the same protein · chain A against A, TM-score 0.83

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q71SY5
Elsewhere: RCSB PDB 2L6U · PDBe 2L6U · UniProt Q71SY5

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