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Solution structure of the zalpha domain mutant of ADAR1 (N43A,Y47A)

Analyse Solution structure of the zalpha domain mutant of ADAR1 (N43A,Y47A) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2L54
Type: protein
Length: 63 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Double-stranded RNA-specific adenosine deaminase
EC: 3.5.4.-
UniProt: P55265
Pockets: 1 · best druggability 0.64

Structure

solution nmr · 1 distinct chain · 54% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Double-stranded RNA-specific adenosine deaminase (EC 3.5.4.-)	protein	63	54% helix, 10% strand	P55265

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	182	0.64	0.84	28	empty

Compared structures

2L54 · Solution structure of the Zalpha domain mutant of ADAR1 (N43A,Y47A) · the same entry in another collection · chain A against A, TM-score 1.00
P55265 · AlphaFold monomer V2.0 prediction for double-stranded RNA-specific adenosine deaminase… · a predicted model of the same protein · chain A against A, TM-score 0.68

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P55265
Elsewhere: RCSB PDB 2L54 · PDBe 2L54 · UniProt P55265

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