Thiostrepton

Structure

solution nmr · 1 distinct chain · 0% helix, 0% strand (DSSP).

Ligands and binding sites

• QUA · 8-hydroxy-4-(1-hydroxyethyl)quinoline-2-carboxylic acid · ligand · chains A
• NH2 · Amino group · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Modifications

Observed in the structure: 10 modified, 2 covalent, 1 d-amino (nonstandard, covalent ligand, D-amino acid).

Compared structures

• 2L2W · Thiostrepton · the same entry in another collection · chain A against A, TM-score 1.00
• 1OLN · Model for thiostrepton antibiotic binding to L11 substrate from 50S ribosomal RNA · a predicted model of the same protein · chain A against B, TM-score 0.72
• 1OLN · Model for thiostrepton antibiotic binding to L11 substrate from 50S ribosomal RNA · a predicted model of the same protein · chain A against B, TM-score 0.72
• P0C8P8 · AlphaFold monomer V2.0 prediction for thiostrepton (P0C8P8) · a predicted model of the same protein · chain A against A, TM-score 0.21

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P0C8P8
• Elsewhere: RCSB PDB 2L2W · PDBe 2L2W · UniProt P0C8P8