UniProt P0C8P8
Thiostrepton (P0C8P8)
Thiostrepton (UniProt P0C8P8): 16 experimental structures and 3 predicted models on GenesisL1. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0C8P8
- Protein
- Thiostrepton
- Experimental structures
- 16
- Predicted models
- 3
Structures
19 records of P0C8P8 in the MolNFT archive: 16 experimental, 3 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1E9W | Structure of the macrocycle thiostrepton solved using the anomalous dispersive contribution from… | x-ray diffraction | A | — | — |
| 1E9W | Structure of the macrocycle thiostrepton solved using the anomalous dispersive contribution from… | x-ray diffraction | A | — | — |
| 2JQ7 | Model for thiostrepton binding to the ribosomal L11-RNA | solution nmr | C | — | — |
| 2JQ7 | Model for thiostrepton binding to the ribosomal L11-RNA | solution nmr | C | — | — |
| 2L2W | Thiostrepton | solution nmr | A | — | — |
| 2L2W | Thiostrepton | solution nmr | A | — | — |
| 2L2X | Thiostrepton, oxidized at CA-CB bond of residue 9 | solution nmr | A | — | — |
| 2L2X | Thiostrepton, oxidized at ca-cb bond of residue 9 | solution nmr | A | — | — |
| 2L2Y | Thiostrepton, epimer form of residue 9 | solution nmr | A | — | — |
| 2L2Y | Thiostrepton, epimer form of residue 9 | solution nmr | A | — | — |
| 2L2Z | Thiostrepton, reduced at N-CA bond of residue 14 | solution nmr | A | — | — |
| 2L2Z | Thiostrepton, reduced at N-ca bond of residue 14 | solution nmr | A | — | — |
| 3CF5 | Thiopeptide antibiotic Thiostrepton bound to the large ribosomal subunit of Deinococcus radiodurans | x-ray diffraction | 5 | — | — |
| 3CF5 | Thiopeptide antibiotic thiostrepton bound to the large ribosomal subunit of deinococcus radiodurans | x-ray diffraction | 5 | — | — |
| 4HP2 | Invariom refinement of a new dimeric monoclinic 2 solvate of thiostrepton at 0.64 angstrom… | x-ray diffraction | A, B | — | — |
| 4HP2 | Invariom refinement of a new dimeric monoclinic 2 solvate of thiostrepton at 0.64 ångström… | x-ray diffraction | A, B | — | — |
| 1OLN | Model for thiostrepton antibiotic binding to L11 substrate from 50S ribosomal RNA | solution nmr, theoretical model | B | — | — |
| 1OLN | Model for thiostrepton antibiotic binding to L11 substrate from 50S ribosomal RNA | solution nmr; theoretical model | B | — | — |
| P0C8P8 | AlphaFold monomer V2.0 prediction for thiostrepton (P0C8P8) | predicted | A | — | — |
Experiment against prediction
- 1E9W chain A against the predicted model 1OLN: TM-score 1.00, RMSD 0.02 Å
- 1E9W chain A against the predicted model 1OLN: TM-score 1.00, RMSD 0.02 Å
- 1E9W chain A against the predicted model 1OLN: TM-score 1.00, RMSD 0.02 Å
- 1E9W chain A against the predicted model 1OLN: TM-score 1.00, RMSD 0.02 Å
- 3CF5 chain 5 against the predicted model 1OLN: TM-score 0.84, RMSD 1.08 Å
- 3CF5 chain 5 against the predicted model 1OLN: TM-score 0.84, RMSD 1.08 Å
- 3CF5 chain 5 against the predicted model 1OLN: TM-score 0.84, RMSD 1.08 Å
- 3CF5 chain 5 against the predicted model 1OLN: TM-score 0.84, RMSD 1.08 Å
- 4HP2 chain B against the predicted model 1OLN: TM-score 0.74, RMSD 0.66 Å
- 4HP2 chain B against the predicted model 1OLN: TM-score 0.74, RMSD 0.66 Å
Elsewhere
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