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Structure of the C-domain fragment of apo calmodulin bound to the iq motif of NAV1.2

Analyse Structure of the C-domain fragment of apo calmodulin bound to the iq motif of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2KXW
Type: protein
Length: 100 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Calmodulin; Sodium channel protein type 2 subunit alpha
UniProt: P07463, P04775

Structure

solution nmr · 2 distinct chains · 59% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Calmodulin	protein	73	55% helix, 10% strand	P07463
B	Sodium channel protein type 2 subunit alpha	protein	27	70% helix, 0% strand	P04775

Interfaces

1 interface between chains.

A–B · 905 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

2KXW · Structure of the C-domain Fragment of apo Calmodulin Bound to the IQ motif of Nav1.2 · the same entry in another collection · chain A against A, TM-score 1.00
P04775 · AlphaFold monomer V2.0 prediction for sodium channel protein type 2 subunit alpha (P04775) · a predicted model of the same protein · chain B against A, TM-score 0.58
P07463 · AlphaFold monomer V2.0 prediction for calmodulin (P07463) · a predicted model of the same protein · chain A against A, TM-score 0.53

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07463
Every structure of UniProt P04775
Elsewhere: RCSB PDB 2KXW · PDBe 2KXW · UniProt P07463 · UniProt P04775

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