MolNFT v1 · #421496 · protein
AlphaFold monomer V2.0 prediction for sodium channel protein type 2 subunit alpha (P04775)
P04775: “AlphaFold monomer V2.0 prediction for sodium channel protein type 2 subunit alpha (P04775)”. 20 pockets (best druggability 0.86). MolNFT v1 #421496 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P04775
- Type
- protein
- Length
- 2,005 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x64a42eb1CDcAc348691EBAf33e0A237997bD2428
- Molecule
- Sodium channel protein type 2 subunit alpha
- UniProt
- P04775
- Pockets
- 20 · best druggability 0.86
Structure
1 distinct chain · 53% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sodium channel protein type 2 subunit alpha | protein | 2005 | 53% helix, 3% strand | P04775 |
Pockets
20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1107 | 0.86 | 0.86 | 86 | empty |
| 2 | 722 | 0.75 | 0.80 | 56 | empty |
| 3 | 1172 | 0.72 | 0.76 | 86 | empty |
| 4 | 526 | 0.68 | 0.78 | 47 | empty |
| 5 | 330 | 0.66 | 0.81 | 38 | empty |
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 2KXW · Structure of the C-domain Fragment of apo Calmodulin Bound to the IQ motif of Nav1.2 · an experimental structure of the same protein · chain A against B, TM-score 0.01
- 2KXW · Structure of the C-domain fragment of apo calmodulin bound to the iq motif of NAV1.2 · an experimental structure of the same protein · chain A against B, TM-score 0.01
- 2M5E · Structure of the C-domain of calcium-saturated calmodulin bound to the iq motif of NAV1.2 · an experimental structure of the same protein · chain A against B, TM-score 0.01
- 2M5E · Structure of the C-domain of Calcium-saturated Calmodulin bound to the IQ motif of NaV1.2 · an experimental structure of the same protein · chain A against B, TM-score 0.01
- 1BYY · Sodium channel iia inactivation gate · an experimental structure of the same protein · chain A against A, TM-score 0.01
- 1BYY · Sodium channel iia inactivation gate · an experimental structure of the same protein · chain A against A, TM-score 0.01
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04775
- Elsewhere: UniProt P04775 · AlphaFold DB P04775
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