Research workbench
Solution NMR structure of V-1 bound to capping protein (cp)
Analyse Solution NMR structure of V-1 bound to capping protein (cp) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2KXP
- Type
- protein
- Length
- 663 residues
- Chains
- 3
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- F-actin-capping protein subunit alpha-1; F-actin-capping protein subunit beta isoforms 1…
- UniProt
- P13127, P14315, P62774
- Pockets
- 10 · best druggability 0.77
Structure
solution nmr · 3 distinct chains · 38% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | F-actin-capping protein subunit alpha-1 | protein | 275 | 36% helix, 23% strand | P13127 |
| B | F-actin-capping protein subunit beta isoforms 1 and 2 | protein | 270 | 38% helix, 28% strand | P14315 |
| C | Myotrophin | protein | 118 | 42% helix, 0% strand | P62774 |
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 741 | 0.77 | 0.81 | 69 | empty |
| 2 | 89 | 0.61 | 0.88 | 27 | empty |
| 3 | 289 | 0.60 | 0.78 | 30 | empty |
| 4 | 251 | 0.58 | 0.79 | 33 | empty |
| 5 | 196 | 0.50 | 0.76 | 29 | empty |
Interfaces
3 interfaces between chains.
- A–B · 3950 Ų buried · 49 hydrogen bonds · protein-protein
- A–C · 431 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 426 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 2KXP · Solution NMR structure of V-1 bound to capping protein (CP) · the same entry in another collection · chain A against A, TM-score 1.00
- P13127 · AlphaFold monomer V2.0 prediction for F-actin-capping protein subunit alpha-1 (P13127) · a predicted model of the same protein · chain A against A, TM-score 0.91
- P14315 · AlphaFold monomer V2.0 prediction for F-actin-capping protein subunit beta isoforms 1 and… · a predicted model of the same protein · chain B against A, TM-score 0.90
- P62774 · AlphaFold monomer V2.0 prediction for myotrophin (P62774) · a predicted model of the same protein · chain C against A, TM-score 0.81
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13127
- Every structure of UniProt P14315
- Every structure of UniProt P62774
- Elsewhere: RCSB PDB 2KXP · PDBe 2KXP · UniProt P13127 · UniProt P14315 · UniProt P62774
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