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NMR dimer structure of the uba domain of P62 (SQSTM1)

Analyse NMR dimer structure of the uba domain of P62 (SQSTM1) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2KNV
Type: protein
Length: 104 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sequestosome-1
UniProt: Q13501
Pockets: 2 · best druggability 0.33

Structure

solution nmr · 1 distinct chain · 54% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Sequestosome-1	protein	52	54% helix, 0% strand	Q13501

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	73	0.33	0.75	18	empty
2	72	0.32	0.74	16	empty

Interfaces

1 interface between chains.

A–B · 574 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

2KNV · NMR dimer structure of the UBA domain of p62 (SQSTM1) · the same entry in another collection · chain A against A, TM-score 1.00
Q13501 · AlphaFold monomer V2.0 prediction for sequestosome-1 (Q13501) · a predicted model of the same protein · chain A against A, TM-score 0.63

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13501
Elsewhere: RCSB PDB 2KNV · PDBe 2KNV · UniProt Q13501

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