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Solution structure of plaa family ubiquitin binding domain (pfuc) cis isomer in complex with ubiquitin

Analyse Solution structure of plaa family ubiquitin binding domain (pfuc) cis isomer in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
2K8B
Type
protein
Length
156 residues
Chains
2
Method
solution nmr
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Ubiquitin; Phospholipase a-2-activating protein
UniProt
P62988, Q9Y263
Pockets
1 · best druggability 0.51

Structure

solution nmr · 2 distinct chains · 24% helix, 27% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AUbiquitinprotein7614% helix, 34% strandP62988
BPhospholipase a-2-activating proteinprotein8034% helix, 20% strandQ9Y263

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
1750.510.8417empty

Interfaces

1 interface between chains.

  • A–B · 775 Ų buried · 12 hydrogen bonds · protein-protein

Compared structures

  • 2K8B · Solution structure of PLAA family ubiquitin binding domain (PFUC) cis isomer in complex… · the same entry in another collection · chain A against A, TM-score 1.00
  • Q9Y263 · AlphaFold monomer V2.0 prediction for phospholipase a-2-activating protein (Q9Y263) · a predicted model of the same protein · chain B against A, TM-score 0.67

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