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Solution structure of the catalytic domain of procaspase-8

Analyse Solution structure of the catalytic domain of procaspase-8 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2K7Z
Type: protein
Length: 229 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Caspase-8
EC: 3.4.22.61
UniProt: Q14790
Pockets: 5 · best druggability 0.79

Structure

solution nmr · 1 distinct chain · 20% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Caspase-8 (EC 3.4.22.61)	protein	229	20% helix, 9% strand	Q14790

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	298	0.79	0.90	44	empty
2	353	0.73	0.84	44	empty
3	220	0.64	0.83	36	empty
4	101	0.45	0.79	24	empty
5	65	0.32	0.75	16	empty

Compared structures

2K7Z · Solution Structure of the Catalytic Domain of Procaspase-8 · the same entry in another collection · chain A against A, TM-score 1.00
Q14790 · AlphaFold monomer V2.0 prediction for caspase-8 (Q14790) · a predicted model of the same protein · chain A against A, TM-score 0.64

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q14790
Elsewhere: RCSB PDB 2K7Z · PDBe 2K7Z · UniProt Q14790

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