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Structure of human guanylate binding protein-1 in nucleotide free form

Analyse Structure of human guanylate binding protein-1 in nucleotide free form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1DG3
Type: protein
Length: 540 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (interferon-induced guanylate-binding protein 1)
UniProt: P32455
Pockets: 7 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 64% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein (interferon-induced guanylate-binding protein 1)	protein	540	64% helix, 11% strand	P32455

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	594	0.69	0.78	69	empty
2	157	0.63	0.85	33	empty
3	163	0.51	0.78	21	empty
4	166	0.50	0.78	25	empty
5	83	0.39	0.78	17	empty

Compared structures

1DG3 · Structure of human guanylate binding protein-1 in nucleotide free form · the same entry in another collection · chain A against A, TM-score 1.00
P32455 · AlphaFold monomer V2.0 prediction for guanylate-binding protein 1 (P32455) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P32455
Elsewhere: RCSB PDB 1DG3 · PDBe 1DG3 · UniProt P32455

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