Research workbench
Solution NMR structure of the non-productive complex between iiamannose and iibmannose of the mannose transporter of the E. COLI phosphotransferase system
Analyse Solution NMR structure of the non-productive complex between iiamannose and… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2JZO
- Type
- protein
- Length
- 423 residues
- Chains
- 3
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pts system mannose-specific eiiab component
- EC
- 2.7.1.69, 2.7.1.-
- UniProt
- P69797
- Pockets
- 2 · best druggability 0.64
Structure
solution nmr · 2 distinct chains · 40% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Pts system mannose-specific eiiab component (EC 2.7.1.69) | protein | 129 | 47% helix, 18% strand | P69797 |
| D | Pts system mannose-specific eiiab component (EC 2.7.1.-) | protein | 165 | 36% helix, 24% strand | P69797 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 496 | 0.64 | 0.76 | 51 | empty |
| 2 | 58 | 0.29 | 0.74 | 17 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1539 Ų buried · 20 hydrogen bonds · protein-protein
- B–D · 261 Ų buried · 2 hydrogen bonds · protein-protein
- A–D · 180 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 2JZO · Solution NMR structure of the non-productive complex between IIAMannose and IIBMannose of… · the same entry in another collection · chain A against A, TM-score 1.00
- P69797 · AlphaFold monomer V2.0 prediction for pts system mannose-specific eiiab component (P69797) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P69797
- Elsewhere: RCSB PDB 2JZO · PDBe 2JZO · UniProt P69797
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