Research workbench

NMR structure of the arid domain from the histone H3K4 demethylase RBP2

Analyse NMR structure of the arid domain from the histone H3K4 demethylase RBP2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2JXJ
Type: protein
Length: 96 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Histone demethylase JARID1A
EC: 1.14.11.-
UniProt: P29375
Pockets: 1 · best druggability 0.59

Structure

solution nmr · 1 distinct chain · 65% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Histone demethylase JARID1A (EC 1.14.11.-)	protein	96	65% helix, 4% strand	P29375

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	58	0.59	0.90	14	empty

Compared structures

2JXJ · NMR structure of the ARID domain from the histone H3K4 demethylase RBP2 · the same entry in another collection · chain A against A, TM-score 1.00
P29375 · AlphaFold monomer V2.0 prediction for lysine-specific demethylase 5A (P29375) · a predicted model of the same protein · chain A against A, TM-score 0.87

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P29375
Elsewhere: RCSB PDB 2JXJ · PDBe 2JXJ · UniProt P29375

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.