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Solution structure of the F153-to-5-flurotryptophan mutant of human cardiac troponin C

Analyse Solution structure of the F153-to-5-flurotryptophan mutant of human cardiac… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2JT8
Type: protein
Length: 161 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Troponin C, slow skeletal and cardiac muscles
UniProt: P63316
Pockets: 3 · best druggability 0.68

Structure

solution nmr · 1 distinct chain · 47% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Troponin C, slow skeletal and cardiac muscles	protein	161	47% helix, 0% strand	P63316

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	357	0.68	0.81	26	empty
2	168	0.46	0.75	23	empty
3	84	0.39	0.77	17	empty

Modifications

Observed in the structure: 1 modified (nonstandard).

Compared structures

2JT8 · Solution structure of the F153-to-5-flurotryptophan mutant of human cardiac troponin C · the same entry in another collection · chain A against A, TM-score 1.00
P63316 · AlphaFold monomer V2.0 prediction for troponin C, slow skeletal and cardiac muscles… · a predicted model of the same protein · chain A against A, TM-score 0.51

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P63316
Elsewhere: RCSB PDB 2JT8 · PDBe 2JT8 · UniProt P63316

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