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Solution structure of MMP20 complexed with nngh

Analyse Solution structure of MMP20 complexed with nngh in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2JSD
Type: protein
Length: 160 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Matrix metalloproteinase-20
EC: 3.4.24.-
UniProt: O60882
Ligands: NGH, CA, ZN
Pockets: 1 · best druggability 0.47

Structure

solution nmr · 1 distinct chain · 26% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Matrix metalloproteinase-20 (EC 3.4.24.-)	protein	160	26% helix, 17% strand	O60882

Ligands and binding sites

NGH · N-isobutyl-N-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid · ligand · chains A
CA · Calcium ion · metal · 2 copies · chains A
ZN · Zinc ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	78	0.47	0.82	18	NGH

Compared structures

2JSD · Solution structure of MMP20 complexed with NNGH · the same entry in another collection · chain A against A, TM-score 1.00
O60882 · AlphaFold monomer V2.0 prediction for matrix metalloproteinase-20 (O60882) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O60882
Elsewhere: RCSB PDB 2JSD · PDBe 2JSD · UniProt O60882

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