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Desheptapeptide (B24-B30) insulin

Analyse Desheptapeptide (B24-B30) insulin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1DEI
Type: protein
Length: 88 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Insulin
UniProt: P01315

Structure

x-ray diffraction · 2 distinct chains · 55% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	Insulin	protein	21	62% helix, 0% strand	P01315
B, D	Insulin	protein	23	48% helix, 0% strand	P01315

Interfaces

6 interfaces between chains.

B–D · 570 Å² buried · 4 hydrogen bonds · protein-protein
C–D · 459 Å² buried · 4 hydrogen bonds · protein-protein
A–B · 447 Å² buried · 3 hydrogen bonds · protein-protein
B–C · 229 Å² buried · 3 hydrogen bonds · protein-protein
A–D · 218 Å² buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

1DEI · Desheptapeptide (B24-B30) insulin · the same entry in another collection · chain A against A, TM-score 1.00
P01315 · AlphaFold monomer V2.0 prediction for insulin (P01315) · a predicted model of the same protein · chain B against A, TM-score 0.42

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01315
Elsewhere: RCSB PDB 1DEI · PDBe 1DEI · UniProt P01315

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