Research workbench
Crystal structure of human STE20-like kinase (unliganded form)
Analyse Crystal structure of human STE20-like kinase (unliganded form) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2JFM
- Type
- protein
- Length
- 288 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- STE20-like serine-threonine kinase
- EC
- 2.7.11.1
- UniProt
- Q9H2G2
- Pockets
- 3 · best druggability 0.59
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | STE20-like serine-threonine kinase (EC 2.7.11.1) | protein | 288 | 40% helix, 17% strand | Q9H2G2 |
Ligands and binding sites
- EDO · 1,2-ethanediol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 263 | 0.59 | 0.79 | 39 | empty |
| 2 | 104 | 0.37 | 0.75 | 21 | empty |
| 3 | 56 | 0.33 | 0.77 | 15 | EDO |
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 2JFM · Crystal structure of human STE20-like kinase (unliganded form) · the same entry in another collection · chain A against A, TM-score 1.00
- Q9H2G2 · AlphaFold monomer V2.0 prediction for STE20-like SERINE/THREONINE- protein kinase (Q9H2G2) · a predicted model of the same protein · chain A against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H2G2
- Elsewhere: RCSB PDB 2JFM · PDBe 2JFM · UniProt Q9H2G2
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