UniProt Q9H2G2
STE20-like serine/threonine-protein kinase (Q9H2G2)
STE20-like serine/threonine-protein kinase (UniProt Q9H2G2), EC 2.7.11.1: 13 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 28 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9H2G2
- Protein
- STE20-like serine/threonine-protein kinase
- EC
- 2.7.11.1
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 28 · 5 records with a druggable one
Structures
14 records of Q9H2G2 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2J51 | Crystal structure of Human STE20-like kinase bound to 5-Amino-3-((4-(aminosulfonyl)phenyl)amino)… | x-ray diffraction | A | SCN, DKI | 3 (best 0.58) |
| 2J51 | Crystal structure of human STE20-like kinase bound to 5… | x-ray diffraction | A | — | — |
| 2JFL | Crystal structure of human STE20-like kinase (diphosphorylated form) bound to 5… | x-ray diffraction | A | DKI, SCN, CL | 3 (best 0.58) |
| 2JFL | Crystal structure of human STE20-like kinase (diphosphorylated form) bound to 5… | x-ray diffraction | A | — | — |
| 2JFM | Crystal structure of human STE20-like kinase (unliganded form) | x-ray diffraction | A | — | 3 (best 0.59) |
| 2JFM | Crystal structure of human STE20-like kinase (unliganded form) | x-ray diffraction | A | — | — |
| 2UV2 | Crystal Structure Of Human Ste20-Like Kinase Bound To 4-(4-(5… | x-ray diffraction | A | — | — |
| 2UV2 | Crystal structure of human STE20-like kinase bound to 4-(4-(5… | x-ray diffraction | A | — | — |
| 4USF | Human SLK with SB-440719 | x-ray diffraction | A, B | — | — |
| 4USF | Human slk with sb-440719 | x-ray diffraction | A, B | — | — |
| 6HVD | Human SLK bound to a maleimide inhibitor | x-ray diffraction | A | GUQ, SO4 | — |
| 6HVD | Human slk bound to a maleimide inhibitor | x-ray diffraction | A | GUQ, SO4 | — |
| 8BEM | STE20-like serine/threonine-protein kinase (SLK) in complex with Tivozanib | x-ray diffraction | A, B, D, G | AV9, SO4 | 12 (best 0.72) |
| Q9H2G2 | AlphaFold monomer V2.0 prediction for STE20-like SERINE/THREONINE- protein kinase (Q9H2G2) | predicted | A | — | 7 (best 0.64) |
Ligands
- SO4 · Sulfate ion · in 3 records
- DKI · 5-amino-3-{[4-(aminosulfonyl)phenyl]amino}-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide · in 2 records
- GUQ · 3-(1,3-benzothiazol-2-ylamino)-4-(2-methoxyphenyl) pyrrole-2,5-dione · in 2 records
- SCN · Thiocyanate ion · in 2 records
- AV9 · Tivozanib · in 1 record
- CL · Chloride ion · in 1 record
Experiment against prediction
- 8BEM chain G against the predicted model Q9H2G2: TM-score 0.96, RMSD 1.36 Å
- 8BEM chain D against the predicted model Q9H2G2: TM-score 0.96, RMSD 1.41 Å
- 8BEM chain A against the predicted model Q9H2G2: TM-score 0.95, RMSD 1.58 Å
- 8BEM chain B against the predicted model Q9H2G2: TM-score 0.95, RMSD 1.63 Å
- 4USF chain A against the predicted model Q9H2G2: TM-score 0.91, RMSD 2.07 Å
- 4USF chain A against the predicted model Q9H2G2: TM-score 0.91, RMSD 2.07 Å
- 6HVD chain A against the predicted model Q9H2G2: TM-score 0.91, RMSD 1.02 Å
- 6HVD chain A against the predicted model Q9H2G2: TM-score 0.91, RMSD 1.02 Å
- 4USF chain B against the predicted model Q9H2G2: TM-score 0.90, RMSD 2.34 Å
- 4USF chain B against the predicted model Q9H2G2: TM-score 0.90, RMSD 2.34 Å
Elsewhere
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