MolNFT v1 · #151694 · protein
Human slk bound to a maleimide inhibitor
6HVD · STE20-like SERINE/THREONINE-protein kinase: “Human slk bound to a maleimide inhibitor”. X-ray diffraction, 2 ligands (GUQ, SO4), 2 pockets (best druggability 0.61). MolNFT v1 #151694 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6HVD
- Type
- protein
- Length
- 286 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- STE20-like SERINE/THREONINE-protein kinase
- EC
- 2.7.11.1
- UniProt
- Q9H2G2
- Ligands
- GUQ, SO4
- Pockets
- 2 · best druggability 0.61
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | STE20-like SERINE/THREONINE-protein kinase (EC 2.7.11.1) | protein | 286 | 41% helix, 18% strand | Q9H2G2 |
Ligands and binding sites
- GUQ · 3-(1,3-benzothiazol-2-ylamino)-4-(2-methoxyphenyl) pyrrole-2,5-dione · ligand · chains A
- SO4 · Sulfate ion · ion · 2 copies · chains A
- EDO · 1,2-ethanediol · additive · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 255 | 0.61 | 0.80 | 32 | GUQ |
| 2 | 99 | 0.37 | 0.75 | 22 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H2G2
- Elsewhere: RCSB PDB 6HVD · PDBe 6HVD · UniProt Q9H2G2
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