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Crystal structure of human plasminogen catalytic domain
Analyse Crystal structure of human plasminogen catalytic domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1DDJ
- Type
- protein
- Length
- 988 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Plasminogen
- EC
- 3.4.21.7
- UniProt
- P00747
- Pockets
- 6 · best druggability 0.59
Structure
x-ray diffraction · 1 distinct chain · 11% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Plasminogen (EC 3.4.21.7) | protein | 247 | 11% helix, 33% strand | P00747 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 124 | 0.59 | 0.85 | 25 | empty |
| 2 | 118 | 0.53 | 0.82 | 23 | empty |
| 3 | 110 | 0.44 | 0.79 | 22 | empty |
| 4 | 116 | 0.44 | 0.78 | 22 | empty |
| 5 | 64 | 0.32 | 0.76 | 16 | empty |
Interfaces
2 interfaces between chains.
- A–B · 563 Ų buried · 7 hydrogen bonds · protein-protein
- C–D · 559 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 24 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00747
- Elsewhere: RCSB PDB 1DDJ · PDBe 1DDJ · UniProt P00747
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