Research workbench
Phob response regulator receiver domain constitutively- active double mutant D53A and Y102C.
Analyse Phob response regulator receiver domain constitutively- active double mutant… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2JBA
- Type
- protein
- Length
- 246 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphate regulon transcriptional regulatory protein phob
- UniProt
- P0AFJ5
- Ligands
- NA
- Pockets
- 2 · best druggability 0.55
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphate regulon transcriptional regulatory protein phob | protein | 125 | 37% helix, 24% strand | P0AFJ5 |
| B | Phosphate regulon transcriptional regulatory protein phob | protein | 121 | 38% helix, 25% strand | P0AFJ5 |
Ligands and binding sites
- NA · Sodium ion · metal · 2 copies · chains A, B
- TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 167 | 0.55 | 0.80 | 24 | NA |
| 2 | 50 | 0.28 | 0.75 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 577 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 2JBA · PhoB response regulator receiver domain constitutively-active double mutant D53A and… · the same entry in another collection · chain A against A, TM-score 1.00
- P0AFJ5 · AlphaFold monomer V2.0 prediction for phosphate regulon transcriptional regulatory… · a predicted model of the same protein · chain B against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AFJ5
- Elsewhere: RCSB PDB 2JBA · PDBe 2JBA · UniProt P0AFJ5
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