Research workbench
Crystal structure of the human filamin a ig domains 19 to 21
Analyse Crystal structure of the human filamin a ig domains 19 to 21 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2J3S
- Type
- protein
- Length
- 498 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Filamin-a
- UniProt
- P21333
- Ligands
- BR
- Pockets
- 12 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Filamin-a | protein | 270 | 4% helix, 52% strand | P21333 |
| B | Filamin-a | protein | 228 | 5% helix, 51% strand | P21333 |
Ligands and binding sites
- BR · Bromide ion · ion · 2 copies · chains A, B
- DIO · 1,4-diethylene dioxide · additive · 4 copies · chains A, B
- GOL · Glycerol · additive
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 327 | 0.63 | 0.79 | 46 | DIO |
| 2 | 101 | 0.50 | 0.82 | 23 | empty |
| 3 | 99 | 0.50 | 0.82 | 24 | DIO |
| 4 | 184 | 0.47 | 0.75 | 31 | empty |
| 5 | 159 | 0.46 | 0.76 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 1133 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21333
- Elsewhere: RCSB PDB 2J3S · PDBe 2J3S · UniProt P21333
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