Research workbench
Crystal structure of socs-4 in complex with elongin-B and elongin-C at 2.55A resolution
Analyse Crystal structure of socs-4 in complex with elongin-B and elongin-C at 2.55A… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2IZV
- Type
- protein
- Length
- 353 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Suppressor of cytokine signaling 4; Transcription elongation factor B polypeptide 2…
- UniProt
- Q8WXH5, Q15370, Q15369
- Ligands
- NA, CL
- Pockets
- 2 · best druggability 0.57
Structure
x-ray diffraction · 3 distinct chains · 30% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Suppressor of cytokine signaling 4 | protein | 163 | 29% helix, 25% strand | Q8WXH5 |
| B | Transcription elongation factor B polypeptide 2 | protein | 105 | 17% helix, 38% strand | Q15370 |
| C | Transcription elongation factor B polypeptide 1 | protein | 85 | 46% helix, 15% strand | Q15369 |
Ligands and binding sites
- NA · Sodium ion · metal · chains A
- CL · Chloride ion · ion · chains A
- EDO · 1,2-ethanediol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 73 | 0.57 | 0.88 | 21 | empty |
| 2 | 106 | 0.44 | 0.78 | 20 | empty |
Interfaces
3 interfaces between chains.
- B–C · 1150 Ų buried · 14 hydrogen bonds · protein-protein
- A–C · 958 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 207 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 2IZV · Crystal structure of socs-4 in complex with elongin-B and elongin-C at 2.55A resolution · the same entry in another collection · chain B against B, TM-score 1.00
- Q15369 · AlphaFold monomer V2.0 prediction for elongin-C (Q15369) · a predicted model of the same protein · chain C against A, TM-score 0.99
- Q15370 · AlphaFold monomer V2.0 prediction for elongin-B (Q15370) · a predicted model of the same protein · chain B against A, TM-score 0.98
- Q8WXH5 · AlphaFold monomer V2.0 prediction for suppressor of cytokine signaling 4 (Q8WXH5) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8WXH5
- Every structure of UniProt Q15370
- Every structure of UniProt Q15369
- Elsewhere: RCSB PDB 2IZV · PDBe 2IZV · UniProt Q8WXH5 · UniProt Q15370 · UniProt Q15369
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