Research workbench

12TH PDZ domain of multiple PDZ domain protein mpdz (casp target)

Analyse 12TH PDZ domain of multiple PDZ domain protein mpdz (casp target) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2IWO
Type: protein
Length: 191 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Multiple PDZ domain protein
UniProt: O75970
Pockets: 2 · best druggability 0.38

Structure

x-ray diffraction · 2 distinct chains · 17% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Multiple PDZ domain protein	protein	92	16% helix, 43% strand	O75970
B	Multiple PDZ domain protein	protein	99	17% helix, 40% strand	O75970

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	69	0.38	0.79	17	empty
2	54	0.29	0.75	12	empty

Interfaces

1 interface between chains.

A–B · 812 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

2IWO · 12th PDZ domain of Multiple PDZ Domain Protein MPDZ · the same entry in another collection · chain A against A, TM-score 1.00
O75970 · AlphaFold monomer V2.0 prediction for multiple PDZ domain protein (O75970) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O75970
Elsewhere: RCSB PDB 2IWO · PDBe 2IWO · UniProt O75970

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.