Research workbench

P. aeruginosa ftsk motor domain, hexamer

Analyse P. aeruginosa ftsk motor domain, hexamer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2IUU
Type: protein
Length: 2,448 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA translocase ftsk
UniProt: Q9I0M3
Ligands: ADP
Pockets: 20 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F	DNA translocase ftsk	protein	408	38% helix, 20% strand	Q9I0M3

Ligands and binding sites

ADP · Adenosine-5'-diphosphate · ligand · 6 copies · chains A, B, C, D, E, F

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1080	0.78	0.80	106	empty
2	803	0.77	0.81	92	empty
3	999	0.77	0.79	100	empty
4	995	0.77	0.79	98	empty
5	1103	0.77	0.79	109	empty

Interfaces

6 interfaces between chains.

D–E · 892 Å² buried · 9 hydrogen bonds · protein-protein
C–D · 891 Å² buried · 10 hydrogen bonds · protein-protein
E–F · 882 Å² buried · 8 hydrogen bonds · protein-protein
A–F · 876 Å² buried · 8 hydrogen bonds · protein-protein
A–B · 867 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

2IUU · P. aeruginosa FtsK motor domain, hexamer · the same entry in another collection · chain F against F, TM-score 1.00
Q9I0M3 · AlphaFold monomer V2.0 prediction for DNA translocase ftsk (Q9I0M3) · a predicted model of the same protein · chain C against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9I0M3
Elsewhere: RCSB PDB 2IUU · PDBe 2IUU · UniProt Q9I0M3

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