Research workbench
Crystal structure of the PI3-kinase P85 N-terminal SH2 domain in complex with pdgfr phosphotyrosyl peptide
Analyse Crystal structure of the PI3-kinase P85 N-terminal SH2 domain in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2IUI
- Type
- protein
- Length
- 239 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphatidylinositol 3-kinase regulatory subunit alpha; Platelet-derived growth factor…
- EC
- 2.7.10.1
- UniProt
- P27986, P09619
- Pockets
- 1 · best druggability 0.49
Structure
x-ray diffraction · 3 distinct chains · 18% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphatidylinositol 3-kinase regulatory subunit alpha | protein | 107 | 20% helix, 28% strand | P27986 |
| B | Phosphatidylinositol 3-kinase regulatory subunit alpha | protein | 110 | 19% helix, 27% strand | P27986 |
| C, D | Platelet-derived growth factor receptor beta (EC 2.7.10.1) | protein | 11 | 0% helix, 9% strand | P09619 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 240 | 0.49 | 0.74 | 22 | empty |
Interfaces
3 interfaces between chains.
- A–C · 685 Ų buried · 20 hydrogen bonds · protein-protein
- B–D · 675 Ų buried · 20 hydrogen bonds · protein-protein
- A–B · 319 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (phosphorylation).
Compared structures
- 2IUI · Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with PDGFR… · the same entry in another collection · chain C against C, TM-score 1.00
- P09619 · AlphaFold monomer V2.0 prediction for platelet-derived growth factor receptor beta… · a predicted model of the same protein · chain C against A, TM-score 0.43
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P27986
- Every structure of UniProt P09619
- Elsewhere: RCSB PDB 2IUI · PDBe 2IUI · UniProt P27986 · UniProt P09619
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