Research workbench
Crystal structure of the PI3-kinase P85 N-terminal SH2 domain in complex with C-kit phosphotyrosyl peptide
Analyse Crystal structure of the PI3-kinase P85 N-terminal SH2 domain in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2IUH
- Type
- protein
- Length
- 123 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphatidylinositol 3-kinase regulatory alpha subunit; C-kit phosphotyrosyl peptide
- UniProt
- P27986, Q8TCG9
Structure
x-ray diffraction · 2 distinct chains · 20% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphatidylinositol 3-kinase regulatory alpha subunit | protein | 115 | 21% helix, 26% strand | P27986 |
| B | C-kit phosphotyrosyl peptide | protein | 8 | 0% helix, 38% strand | Q8TCG9 |
Interfaces
1 interface between chains.
- A–B · 686 Ų buried · 23 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 2IUH · Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with c-Kit… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P27986
- Every structure of UniProt Q8TCG9
- Elsewhere: RCSB PDB 2IUH · PDBe 2IUH · UniProt P27986 · UniProt Q8TCG9
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.