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Crystal structure of the polymerase domain from mycobacterium tuberculosis ligase D with GTP and manganese.
Analyse Crystal structure of the polymerase domain from mycobacterium tuberculosis… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2IRX
- Type
- protein
- Length
- 283 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA ligase-like protein RV0938/MT0965
- EC
- 2.7.7.-
- UniProt
- P71571
- Ligands
- GTP, MN
- Pockets
- 2 · best druggability 0.39
Structure
x-ray diffraction · 1 distinct chain · 29% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA ligase-like protein RV0938/MT0965 (EC 2.7.7.-) | protein | 283 | 29% helix, 28% strand | P71571 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 114 | 0.39 | 0.76 | 21 | MN, GTP |
| 2 | 52 | 0.36 | 0.79 | 14 | empty |
Compared structures
- 2IRX · Crystal Structure of the Polymerase Domain from Mycobacterium tuberculosis Ligase D with… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P71571
- Elsewhere: RCSB PDB 2IRX · PDBe 2IRX · UniProt P71571
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