Research workbench
Structure of a human ASF1A-hira complex and insights into specificity of histone chaperone complex assembly
Analyse Structure of a human ASF1A-hira complex and insights into specificity of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2I32
- Type
- protein
- Length
- 345 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Anti-silencing factor 1 paralog a; Histone regulatory homolog a
- UniProt
- Q9Y294, P54198
- Pockets
- 2 · best druggability 0.44
Structure
x-ray diffraction · 3 distinct chains · 9% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Anti-silencing factor 1 paralog a | protein | 154 | 12% helix, 51% strand | Q9Y294 |
| E | Histone regulatory homolog a | protein | 21 | 0% helix, 48% strand | P54198 |
| F | Histone regulatory homolog a | protein | 16 | 0% helix, 50% strand | P54198 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 145 | 0.44 | 0.76 | 23 | empty |
| 2 | 51 | 0.24 | 0.72 | 16 | empty |
Interfaces
4 interfaces between chains.
- A–E · 749 Ų buried · 18 hydrogen bonds · protein-protein
- B–F · 529 Ų buried · 14 hydrogen bonds · protein-protein
- A–F · 192 Ų buried · 1 hydrogen bond · protein-protein
- A–B · 60 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2I32 · Structure of a human ASF1a-HIRA complex and insights into specificity of histone… · the same entry in another collection · chain F against F, TM-score 1.00
- Q9Y294 · AlphaFold monomer V2.0 prediction for histone chaperone ASF1A (Q9Y294) · a predicted model of the same protein · chain A against A, TM-score 0.99
- P54198 · AlphaFold monomer V2.0 prediction for protein hira (P54198) · a predicted model of the same protein · chain F against A, TM-score 0.52
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y294
- Every structure of UniProt P54198
- Elsewhere: RCSB PDB 2I32 · PDBe 2I32 · UniProt Q9Y294 · UniProt P54198
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