UniProt Q9Y294
Histone chaperone ASF1A (Q9Y294)
Histone chaperone ASF1A (UniProt Q9Y294): 25 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 47 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9Y294
- Protein
- Histone chaperone ASF1A
- Experimental structures
- 25
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 47 · 7 records with a druggable one
Structures
26 records of Q9Y294 in the MolNFT archive: 25 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1TEY | NMR structure of human histone chaperone, ASF1A | solution nmr | A | — | — |
| 1TEY | NMR structure of human histone chaperone, ASF1A | solution nmr | A | — | — |
| 2I32 | Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex… | x-ray diffraction | A, B | — | — |
| 2I32 | Structure of a human ASF1A-hira complex and insights into specificity of histone chaperone complex… | x-ray diffraction | A, B | — | — |
| 3AAD | Structure of the histone chaperone CIA/ASF1-double bromodomain complex linking histone… | x-ray diffraction | B, D | — | — |
| 3AAD | Structure of the histone chaperone CIA/ASF1-double bromodomain complex linking histone… | x-ray diffraction | B, D | — | — |
| 5C3I | Crystal structure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and… | x-ray diffraction | A, E, I, M, Q, U | — | — |
| 5C3I | Crystal structure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and… | x-ray diffraction | A, E, I, M, Q, U | — | — |
| 6F0F | Crystal structure ASF1-ip2_s | x-ray diffraction | A | — | — |
| 6F0F | Crystal structure ASF1-IP2_S | x-ray diffraction | A | — | — |
| 6F0G | Crystal structure ASF1-ip3 | x-ray diffraction | A, B | SO4 | 2 (best 0.57) |
| 6F0G | Crystal structure ASF1-IP3 | x-ray diffraction | A, B | SO4 | — |
| 6F0H | Crystal structure ASF1-ip4 | x-ray diffraction | A, C | SO4 | 3 (best 0.55) |
| 6F0H | Crystal structure ASF1-IP4 | x-ray diffraction | A, C | SO4 | — |
| 6ZUF | Urea-based Foldamer Inhibitor chimera C2 in complex with ASF1 Histone chaperone | x-ray diffraction | A, B | SO4 | 1 (best 0.39) |
| 6ZUF | Urea-based foldamer inhibitor chimera C2 in complex with ASF1 histone chaperone | x-ray diffraction | A, B | URL, SO4 | — |
| 7LNY | Apo structure of the Histone chaperone ASF1A residues 1-155 | x-ray diffraction | A, B, C, D, E, F, G | — | 10 (best 0.81) |
| 7LNY | Apo structure of the histone chaperone ASF1A residues 1-155 | x-ray diffraction | A, B, C, D, E, F, G | — | — |
| 7LO0 | Structure of human ASF1A in complex with a TLK2 peptide | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 7V6Q | Crystal structure of snasp-ASF1A-H3.1-H4 complex | x-ray diffraction | A, E | — | — |
| 8BV1 | Peptide inhibitor P4 in complex with ASF1 histone chaperone | x-ray diffraction | A, B, C, D, E, F | — | 9 (best 0.72) |
| 8CJ1 | Urea-based foldamer inhibitor c3u_3 chimera in complex with ASF1 histone chaperone | x-ray diffraction | A, B, C, D, E, F, G, H | — | 14 (best 0.75) |
| 8CJ2 | Urea-based foldamer inhibitor c3u_5 chimera in complex with ASF1 histone chaperone | x-ray diffraction | A, B, C, D | SO4 | 5 (best 0.76) |
| 8CJ3 | Urea-based foldamer inhibitor c3u_7 chimera in complex with ASF1 histone chaperone | x-ray diffraction | A | — | — |
| 8Z50 | Crystal structure of the ASF1-H3T-H4 complex | x-ray diffraction | A | — | 3 (best 0.52) |
| Q9Y294 | AlphaFold monomer V2.0 prediction for histone chaperone ASF1A (Q9Y294) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8BV1 chain C against the predicted model Q9Y294: TM-score 0.99, RMSD 0.33 Å
- 6F0H chain A against the predicted model Q9Y294: TM-score 0.99, RMSD 0.33 Å
- 6F0H chain A against the predicted model Q9Y294: TM-score 0.99, RMSD 0.33 Å
- 6F0H chain C against the predicted model Q9Y294: TM-score 0.99, RMSD 0.36 Å
- 6F0H chain C against the predicted model Q9Y294: TM-score 0.99, RMSD 0.36 Å
- 8BV1 chain E against the predicted model Q9Y294: TM-score 0.99, RMSD 0.37 Å
- 7LO0 chain E against the predicted model Q9Y294: TM-score 0.99, RMSD 0.38 Å
- 6F0G chain A against the predicted model Q9Y294: TM-score 0.99, RMSD 0.38 Å
- 6F0G chain A against the predicted model Q9Y294: TM-score 0.99, RMSD 0.38 Å
- 7LO0 chain H against the predicted model Q9Y294: TM-score 0.99, RMSD 0.38 Å
Elsewhere
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