Research workbench

Cfms tyrosine kinase (FGF kid) in complex with an arylamide inhibitor

Analyse Cfms tyrosine kinase (FGF kid) in complex with an arylamide inhibitor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2I0Y
Type: protein
Length: 289 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cfms tyrosine kinase
EC: 2.7.10.1
UniProt: P07333
Ligands: 5CN
Pockets: 2 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cfms tyrosine kinase (EC 2.7.10.1)	protein	289	38% helix, 19% strand	P07333

Ligands and binding sites

5CN · 5-cyano-furan-2-carboxylic acid [5-hydroxymethyl-2-(4-methyl-piperidin-1-yl)-phenyl]-amide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	237	0.64	0.82	41	5CN
2	89	0.37	0.76	19	empty

Compared structures

2I0Y · cFMS tyrosine kinase (FGF KID) in complex with an arylamide inhibitor · the same entry in another collection · chain A against A, TM-score 1.00
P07333 · AlphaFold monomer V2.0 prediction for macrophage colony-stimulating factor 1 receptor… · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07333
Elsewhere: RCSB PDB 2I0Y · PDBe 2I0Y · UniProt P07333

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