Research workbench
Crystal structure of the GLUR6 ligand binding core dimer crosslinked by disulfide bonds between Y490C and L752C at 2.25 ångströms resolution
Analyse Crystal structure of the GLUR6 ligand binding core dimer crosslinked by… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2I0C
- Type
- protein
- Length
- 513 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate receptor, ionotropic kainate 2
- UniProt
- P42260
- Ligands
- GLU
- Pockets
- 4 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutamate receptor, ionotropic kainate 2 | protein | 257 | 39% helix, 22% strand | P42260 |
| B | Glutamate receptor, ionotropic kainate 2 | protein | 256 | 38% helix, 21% strand | P42260 |
Ligands and binding sites
- GLU · Glutamic acid · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1084 | 0.84 | 0.85 | 96 | empty |
| 2 | 156 | 0.59 | 0.83 | 39 | GLU |
| 3 | 89 | 0.43 | 0.79 | 17 | empty |
| 4 | 69 | 0.32 | 0.75 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 709 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 2I0C · Crystal structure of the GluR6 ligand binding core dimer crosslinked by disulfide bonds… · the same entry in another collection · chain A against A, TM-score 1.00
- P42260 · AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, kainate 2 (P42260) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P42260
- Elsewhere: RCSB PDB 2I0C · PDBe 2I0C · UniProt P42260
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