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Insulin receptor (domains 1-3)

Analyse Insulin receptor (domains 1-3) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2HR7
Type: protein
Length: 929 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Insulin receptor
EC: 2.7.1.112
UniProt: P06213
Ligands: NAG, MAN, BMA, FUC, SO4
Pockets: 13 · best druggability 0.76

Structure

x-ray diffraction · 2 distinct chains · 12% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Insulin receptor (EC 2.7.1.112)	protein	465	12% helix, 30% strand	P06213
B	Insulin receptor (EC 2.7.1.112)	protein	464	13% helix, 29% strand	P06213

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 26 copies · chains A, B
MAN · alpha-D-mannopyranose · sugar · 10 copies · chains A, B
BMA · beta-D-mannopyranose · sugar · 6 copies
FUC · alpha-L-fucopyranose · sugar · 6 copies · chains A, B
SO4 · Sulfate ion · ion · 8 copies · chains A, B
GOL · Glycerol · additive · 19 copies · chains A, B
P33 · 3,6,9,12,15,18-hexaoxaicosane-1,20-diol · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

13 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	196	0.76	0.91	28	P33
2	309	0.56	0.76	28	empty
3	388	0.55	0.74	43	GOL
4	130	0.54	0.82	27	NAG
5	148	0.53	0.80	27	GOL

Interfaces

1 interface between chains.

A–B · 1811 Å² buried · 21 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 32 disulfide, 15 glycan (disulfide, N-glycosylation).

Compared structures

2HR7 · Insulin receptor (domains 1-3) · the same entry in another collection · chain A against A, TM-score 1.00
P06213 · AlphaFold monomer V2.0 prediction for insulin receptor (P06213) · a predicted model of the same protein · chain B against A, TM-score 0.85

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06213
Elsewhere: RCSB PDB 2HR7 · PDBe 2HR7 · UniProt P06213

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