Research workbench

Sumo protease ULP1 with the catalytic cysteine oxidized to a sulfenic acid

Analyse Sumo protease ULP1 with the catalytic cysteine oxidized to a sulfenic acid in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2HKP
Type: protein
Length: 219 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ubiquitin-like-specific protease 1
EC: 3.4.22.-
UniProt: Q02724
Pockets: 2 · best druggability 0.37

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ubiquitin-like-specific protease 1 (EC 3.4.22.-)	protein	219	45% helix, 17% strand	Q02724

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	75	0.37	0.77	18	empty
2	73	0.35	0.76	17	empty

Modifications

Observed in the structure: 1 modified (oxidation).

Compared structures

2HKP · SUMO protease Ulp1 with the catalytic cysteine oxidized to a sulfenic acid · the same entry in another collection · chain A against A, TM-score 1.00
Q02724 · AlphaFold monomer V2.0 prediction for ubiquitin-like-specific protease 1 (Q02724) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q02724
Elsewhere: RCSB PDB 2HKP · PDBe 2HKP · UniProt Q02724

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