Research workbench
Ribonuclease inhibitor-angiogenin complex
Analyse Ribonuclease inhibitor-angiogenin complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1A4Y
- Type
- protein
- Length
- 1,166 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ribonuclease inhibitor; Angiogenin
- EC
- 3.1.27.-
- UniProt
- P13489, P03950
- Pockets
- 10 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | Ribonuclease inhibitor | protein | 460 | 40% helix, 13% strand | P13489 |
| B, E | Angiogenin (EC 3.1.27.-) | protein | 123 | 24% helix, 28% strand | P03950 |
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 720 | 0.71 | 0.78 | 66 | empty |
| 2 | 413 | 0.69 | 0.81 | 58 | empty |
| 3 | 374 | 0.68 | 0.81 | 43 | empty |
| 4 | 107 | 0.63 | 0.88 | 21 | empty |
| 5 | 82 | 0.62 | 0.90 | 17 | empty |
Interfaces
5 interfaces between chains.
- A–D · 1826 Ų buried · 24 hydrogen bonds · protein-protein
- D–E · 1467 Ų buried · 23 hydrogen bonds · protein-protein
- A–B · 1453 Ų buried · 23 hydrogen bonds · protein-protein
- A–E · 36 Ų buried · 0 hydrogen bonds · protein-protein
- B–D · 35 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 1A4Y · Ribonuclease inhibitor-angiogenin complex · the same entry in another collection · chain A against A, TM-score 1.00
- P13489 · AlphaFold monomer V2.0 prediction for ribonuclease inhibitor (P13489) · a predicted model of the same protein · chain A against A, TM-score 0.99
- P03950 · AlphaFold monomer V2.0 prediction for angiogenin (P03950) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13489
- Every structure of UniProt P03950
- Elsewhere: RCSB PDB 1A4Y · PDBe 1A4Y · UniProt P13489 · UniProt P03950
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