Research workbench
Crystal structure of a ternary ligand-receptor complex of bmp-2
Analyse Crystal structure of a ternary ligand-receptor complex of bmp-2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2H64
- Type
- protein
- Length
- 291 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bone morphogenetic protein 2; Bone morphogenetic protein receptor type ia; ACVR2B protein
- EC
- 2.7.11.30
- UniProt
- P12643, P36894, Q3KQI1
- Pockets
- 5 · best druggability 0.50
Structure
x-ray diffraction · 3 distinct chains · 10% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Bone morphogenetic protein 2 | protein | 105 | 18% helix, 45% strand | P12643 |
| B | Bone morphogenetic protein receptor type ia (EC 2.7.11.30) | protein | 92 | 7% helix, 35% strand | P36894 |
| C | ACVR2B protein | protein | 94 | 3% helix, 46% strand | Q3KQI1 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 160 | 0.50 | 0.78 | 26 | empty |
| 2 | 113 | 0.46 | 0.79 | 20 | empty |
| 3 | 109 | 0.38 | 0.74 | 16 | empty |
| 4 | 97 | 0.34 | 0.73 | 22 | empty |
| 5 | 52 | 0.28 | 0.75 | 19 | empty |
Interfaces
2 interfaces between chains.
- A–C · 702 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 443 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 13 disulfide (disulfide).
Compared structures
- 2H64 · Crystal structure of a ternary ligand-receptor complex of BMP-2 · the same entry in another collection · chain A against A, TM-score 1.00
- P12643 · AlphaFold monomer V2.0 prediction for bone morphogenetic protein 2 (P12643) · a predicted model of the same protein · chain A against A, TM-score 0.96
- P36894 · AlphaFold monomer V2.0 prediction for bone morphogenetic protein receptor type-1A (P36894) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12643
- Every structure of UniProt P36894
- Every structure of UniProt Q3KQI1
- Elsewhere: RCSB PDB 2H64 · PDBe 2H64 · UniProt P12643 · UniProt P36894 · UniProt Q3KQI1
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